Related Experiment Video

Updated: Sep 23, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.2K

Epidemiology and outcomes of septic shock in children with complex chronic conditions in a developing country PICU

Leandra Rech1, Ian Teixeira E Sousa1, Cristian Tedesco Tonial2

  • 1Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Porto Alegre, RS, Brazil.

Jornal De Pediatria
|May 13, 2022
PubMed

Insights

Complex Chronic Conditions (CCCs) significantly increase mortality and hospital stay in pediatric septic shock patients. The Pediatric Index of Mortality-2 (PELOD-2) score at 48 hours effectively predicts mortality in this high-risk group.

Area of Science:

  • Pediatric critical care medicine
  • Septic shock research
  • Complex chronic conditions epidemiology

Background:

  • Septic shock in children presents significant mortality risks.
  • Complex Chronic Conditions (CCCs) may exacerbate outcomes in pediatric septic shock.
  • Predictive scoring systems are crucial for managing pediatric septic shock.

Purpose of the Study:

  • To evaluate the impact of Complex Chronic Conditions (CCCs) on pediatric septic shock outcomes.
  • To assess the accuracy of the Pediatric Index of Mortality-2 (PELOD-2) and Vasoactive Inotropic Score (VIS) in predicting mortality for pediatric septic shock patients with CCCs.

Main Methods:

  • Retrospective cohort study of pediatric septic shock patients requiring vasoactive drugs.
  • Data collected from electronic medical records at a single center in southern Brazil.
  • Analysis included demographic data, CCC presence, VIS, PELOD-2 scores, and PICU mortality.

Main Results:

  • 72% of 218 pediatric septic shock patients had at least one CCC, with an overall mortality of 22%.
  • Patients with CCCs exhibited higher mortality (26.7% vs 9.8%) and longer hospital stays compared to those without.
  • Malignancy as a CCC was strongly associated with mortality; PELOD-2 at 48 hours (>8) showed high accuracy (AUROC=0.89) in predicting mortality.

Conclusions:

  • Complex Chronic Conditions are prevalent in pediatric septic shock and associated with adverse outcomes.
  • Patients with CCCs represent a vulnerable population requiring prioritized healthcare resource allocation.
  • PELOD-2 at 48 hours is a valuable tool for predicting mortality in pediatric septic shock patients with CCCs.
Abstract

Keywords:
Complex chronic conditionsPediatric critical careSepsis

More Related Videos

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.1K
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.3K

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
467
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
114
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
66
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
109
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
53
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
92