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Updated: Sep 23, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
Cigdem Gelegen1,2, Diana Cash1,3, Katarina Ilic1,4
1Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK.
Abstract:
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.
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