Related Experiment Video
Updated: Sep 23, 2025
07:16
An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
Published on: November 30, 2022
3.6K
COVID-19 and corticosteroids: a narrative review
Gaber El-Saber Batiha1, Ali I Al-Gareeb2, Hebatallah M Saad3
1Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, AlBeheira, Egypt. gaberbatiha@gmail.com.
Inflammopharmacology
|May 13, 2022
Summary
Corticosteroid therapy effectively manages COVID-19 by reducing acute respiratory distress syndrome (ARDS) and cytokine storm, despite potential impacts on viral clearance. This treatment is crucial for critical patients, lowering complication risks.
Area of Science:
- Medical Science
- Pharmacology
Background:
- Corticosteroid therapy has shown efficacy in managing severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS), and coronavirus disease 2019 (COVID-19).
- These potent anti-inflammatory drugs can mitigate the risk of acute respiratory distress syndrome (ARDS) in viral pneumonia, including COVID-19.
Purpose of the Study:
- To evaluate the effectiveness of corticosteroid therapy in managing COVID-19.
- To assess the role of corticosteroids in preventing complications like ARDS and cytokine storm.
Main Methods:
- Review of existing literature on corticosteroid use in viral respiratory illnesses.
- Analysis of the anti-inflammatory mechanisms of corticosteroids in the context of COVID-19.
Main Results:
- Corticosteroids inhibit cytokine storm and multi-organ damage, reducing the risk of ARDS in COVID-19 patients.
- Therapy, particularly with dexamethasone and methylprednisolone, reduces COVID-19 severity and complications like acute lung injury.
Conclusions:
- Corticosteroid therapy is an effective management strategy for COVID-19, reducing complication risks.
- These agents are beneficial for COVID-19 patients with comorbidities such as COPD, rheumatoid arthritis, and IBD.
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
372
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
372
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
406
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
406
01:20Asthma: Pathogenesis and Management
676
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
676
01:20COPD: Pathogenesis and Clinical Features
589
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
589
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
219
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
219
01:14Myocarditis III: Medical Management
24
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
24