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Updated: Sep 23, 2025
09:26
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
Published on: June 6, 2025
676
The Endolysosomal System: The Acid Test for SARS-CoV-2.
Daniella Cesar-Silva1, Filipe S Pereira-Dutra1, Ana Lucia Moraes Giannini2
1Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.
International Journal of Molecular Sciences
|May 14, 2022
Summary
The endolysosomal system is crucial for cell defense and homeostasis. Viruses like SARS-CoV-2 exploit these pathways, highlighting viral subversion strategies for replication and immune evasion.
Area of Science:
- Cell Biology
- Virology
- Immunology
Background:
- The endolysosomal system maintains cellular homeostasis and plays a key role in host defense mechanisms.
- Viruses have evolved sophisticated strategies to interact with and manipulate host cell machinery.
Purpose of the Study:
- To review the diverse functions of the endolysosomal system.
- To discuss how viruses, particularly SARS-CoV-2, subvert endolysosomal pathways for their replication and propagation.
Main Methods:
- Literature review of existing research on endolysosomal function and viral interactions.
- Analysis of host-pathogen interactions focusing on viral manipulation of cellular organelles.
Main Results:
- The endolysosomal system is essential for cellular defense against pathogens.
- Viruses, including coronaviruses, adeptly hijack endolysosomal compartments to facilitate their life cycle.
- Pathogens have developed diverse mechanisms to evade or manipulate lysosomal functions.
Conclusions:
- Understanding endolysosomal system functions is critical for comprehending viral pathogenesis.
- Targeting viral subversion of the endolysosomal system presents potential therapeutic avenues.
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