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Petr Slepička1, Silvie Rimpelová2, Vladimíra Svobodová Pavlíčková2

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Summary

Laser treatment created nanopatterns on aromatic polymers, guiding cell growth for applications in tissue engineering and sensors. This study optimized laser conditions for effective surface modification and cell compatibility.

Keywords:
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Area of Science:

  • Materials Science
  • Surface Engineering
  • Biomaterials

Background:

  • Nanopatterning enhances polymer properties for advanced applications.
  • Laser-induced periodic surface structures (LIPSS) offer precise surface modification.
  • Aromatic polymers like PEN, PES, and PS are suitable for laser processing due to their properties.

Purpose of the Study:

  • To achieve nanopatterning on aromatic polymer substrates using KrF excimer laser treatment.
  • To optimize laser parameters (fluence, pulses) for LIPSS formation.
  • To evaluate the cytocompatibility and cell guidance capabilities of the nanopatterned surfaces.

Main Methods:

  • KrF excimer laser treatment of polyethylene naphthalate (PEN), polyethersulfone (PES), and polystyrene (PS).
  • Surface characterization using atomic force microscopy (AFM), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) analysis, and X-ray photoelectron spectroscopy (XPS).
  • In vitro cytocompatibility tests with human osteosarcoma (U-2 OS) cells.

Main Results:

  • Successful fabrication of LIPSS on PEN, PES, and PS substrates.
  • Optimized laser conditions (10 mJ·cm⁻² with 1000, 3000, 6000 pulses) yielded consistent nanopatterns.
  • Demonstrated significant cell guidance, adhesion, and proliferation on nanopatterned surfaces.
  • Characterization confirmed changes in surface morphology, roughness, and elemental composition.

Conclusions:

  • KrF excimer laser treatment is effective for nanopatterning aromatic polymers.
  • The resulting LIPSS patterns influence cell behavior, showing potential for cell guidance.
  • Nanopatterned polymers have promising applications in tissue engineering, cell analysis, and sensor development.