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Exploring Diverse Coagulation Factor XIII Subunit Expression Datasets: A Bioinformatic Analysis.

Muhammad Ahmer Jamil1, Sneha Singh1, Osman El-Maarri1

  • 1Institute of Experimental Hematology and Transfusion Medicine, University Hospital of Bonn, Building 043, Venusberg Campus 1, 53127 Bonn, Germany.

International Journal of Molecular Sciences
|May 14, 2022
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Summary

Coagulation factor XIII (FXIII) subunits F13A1 and F13B show transcript-level regulation. This study analyzes FXIII gene expression in macrophages and hepatocytes, predicting FXIIIA2

Keywords:
FXIIIRNA-SeqTRANSFACdifferential gene expressionexpression profilinggene ontologyingenuity pathway analysismicro-array

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Hematology

Background:

  • Coagulation factor XIII (FXIII) is a heterotetrameric complex (FXIIIA2B2) essential for fibrin stabilization.
  • FXIII comprises catalytic FXIIIA2 (F13A1 gene) and regulatory FXIIIB2 (F13B gene) subunits.
  • FXIIIA2 originates from macrophages, while FXIIIB2 is hepatocyte-derived, with their genetic regulation poorly understood.

Purpose of the Study:

  • To investigate the genetic regulation of FXIII subunits F13A1 and F13B using a bioinformatic approach.
  • To analyze temporal gene expression data of FXIII subunits in specific cell lineages.
  • To understand the regulatory mechanisms of FXIIIA2 in macrophages and FXIIIB2 in hepatocytes.

Main Methods:

  • Bioinformatic analysis of publicly available microarray data.
  • Examination of time-specific gene expression arrays for F13A1 and F13B.
  • Correlation analysis of differentially expressed genes with F13A1 and F13B expression levels.

Main Results:

  • Transcript-level regulatory dependence was observed between F13A1 and F13B.
  • FXIIIA2 subunit expression patterns were analyzed in various macrophage subtypes (M0, M1, M2, resident).
  • FXIIIB2 subunit expression was analyzed in hepatocytes and hESC-derived hepatoblasts.

Conclusions:

  • The study reveals transcript-level co-regulation between FXIII subunits.
  • FXIIIA2 subunit involvement is predicted in macrophage polarization, plaque stability, and inflammation.
  • This bioinformatic approach provides insights into FXIII subunit genetic regulation.