Related Experiment Video
Updated: Sep 23, 2025
14:54
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
8.8K
Ocular Ischemic Syndrome and Its Related Experimental Models
Deokho Lee1,2, Yohei Tomita1,2,3, Lizhu Yang1,2
1Laboratory of Photobiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
International Journal of Molecular Sciences
|May 14, 2022
Summary
Ocular ischemic syndrome (OIS) arises from carotid artery issues causing poor blood flow to the eye. This review explores OIS pathophysiology, experimental models, and therapies to improve treatment strategies.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Biology
Background:
- Ocular ischemic syndrome (OIS) is a severe ocular disorder linked to carotid artery stenosis or occlusion.
- Carotid artery issues can lead to chronic ocular hypoperfusion, contributing to OIS development.
- The precise pathophysiology of OIS remains incompletely understood.
Purpose of the Study:
- To review the pathophysiology of OIS using experimental models and clinical cases.
- To summarize current therapeutic strategies for OIS.
- To highlight promising preclinical treatments and recent advances for OIS.
Main Methods:
- Review of existing literature on OIS pathophysiology.
- Analysis of experimental models in rats and mice involving carotid artery occlusion/stenosis.
- Compilation of clinical case studies and therapeutic outcomes.
Main Results:
- Experimental models show varied ocular outcomes despite similar hypoperfusion, depending on surgical techniques.
- Current therapies for OIS are discussed.
- Emerging preclinical treatments offer potential for future OIS management.
Conclusions:
- A comprehensive understanding of OIS pathophysiology is crucial for effective treatment.
- Experimental models provide insights into OIS mechanisms.
- Advances in preclinical research pave the way for improved OIS therapeutic approaches.
