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Novel Tumor-Targeting Nanoparticles for Cancer Treatment-A Review
Adelina-Gabriela Niculescu1, Alexandru Mihai Grumezescu1,2,3
1Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.
Abstract:
Being one of the leading causes of death and disability worldwide, cancer represents an ongoing interdisciplinary challenge for the scientific community. As currently used treatments may face limitations in terms of both efficiency and adverse effects, continuous research has been directed towards overcoming existing challenges and finding safer specific alternatives. In particular, increasing interest has been gathered around integrating nanotechnology in cancer management and subsequentially developing various tumor-targeting nanoparticles for cancer applications. In this respect, the present paper briefly describes the most used cancer treatments in clinical practice to set a reference framework for recent research findings, further focusing on the novel developments in the field. More specifically, this review elaborates on the top recent studies concerning various nanomaterials (i.e., carbon-based, metal-based, liposomes, cubosomes, lipid-based, polymer-based, micelles, virus-based, exosomes, and cell membrane-coated nanomaterials) that show promising potential in different cancer applications.
Insights
Researchers are exploring nanotechnology for advanced cancer treatment. Various nanomaterials show promise for targeted cancer therapies, offering safer and more effective alternatives to current methods.
Area of Science:
- Oncology
- Nanotechnology
- Materials Science
Background:
- Cancer remains a major global health challenge, driving the need for improved treatments.
- Existing cancer therapies have limitations in efficacy and side effect profiles.
- Nanotechnology offers innovative solutions for targeted cancer management.
Purpose of the Study:
- To review current cancer treatment modalities.
- To highlight recent advancements in nanotechnology for cancer therapy.
- To explore diverse nanomaterials for tumor-targeting applications.
Main Methods:
- Literature review of clinical cancer treatments.
- Analysis of recent research on nanomaterials in oncology.
- Categorization of various nanomaterial types for cancer applications.
Main Results:
- Nanotechnology integration is a key focus in developing novel cancer treatments.
- Numerous nanomaterials including liposomes, micelles, and exosomes demonstrate significant potential.
- These nanomaterials offer promising tumor-targeting capabilities.
Conclusions:
- Nanotechnology-based approaches are revolutionizing cancer treatment strategies.
- Diverse nanomaterials provide a versatile platform for enhancing cancer therapy efficacy and safety.
- Continued research into nanomaterials is crucial for future cancer management.
