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Induction of Accelerated Aging in a Mouse Model.

Nanshuo Cai¹, Yifan Wu¹, Yan Huang¹

¹MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research and State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

|May 14, 2022

Summary

Aging research relies on animal models, particularly mice, due to their similarities to humans. This review covers common and emerging mouse models for studying aging and related diseases.

Keywords:

aging aging-related disease mouse model

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Area of Science:

Gerontology and Biomedical Research

Background:

Global aging population necessitates advancements in treating age-related diseases and extending healthspan.
Understanding aging mechanisms requires robust animal models.

Purpose of the Study:

To review common and emerging mouse models for accelerated aging and related chronic diseases.
To provide a reference for future research in aging and translational medicine.

Main Methods:

Literature review of recent studies on mouse models of aging.
Focus on models relevant to chronic age-related diseases.

Main Results:

Mice are highly utilized due to genetic and physiological similarities to humans, short lifespans, and reproductive ease.
Discussion of various established and novel mouse models.

Conclusions:

Mouse models are critical tools for investigating aging processes and age-related pathologies.
This review serves as a guide for selecting appropriate models in aging research.