Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

Related Experiment Video

Updated: Sep 23, 2025

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
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Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

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Gael Galli1,2,3, Pierre Vacher4, Bernhard Ryffel5

  • 1CNRS, ImmunoConcEpT, UMR 5164, University Bordeaux, 33000 Bordeaux, France.

Cells
|May 14, 2022
PubMed

Insights

CD95 receptor signaling is complex, influencing cell death and inflammation. New research explores how CD95 connects to damage-associated molecular pattern (DAMP) sensors, potentially impacting inflammatory diseases and cancer.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Signaling

Background:

  • CD95 (Fas/APO-1) receptor engagement initiates complex signaling pathways.
  • The dynamic nature of CD95 protein-protein interactions (PPIs) complicates predicting cellular outcomes.
  • CD95 activation can lead to diverse cellular responses, including apoptosis, necroptosis, pyroptosis, and pro-inflammatory pathways like NF-κB and PI3K.

Purpose of the Study:

  • To explore the molecular links between CD95 signaling and pattern recognition receptors (PRRs).
  • To understand how CD95 activation may contribute to sensing damage-associated molecular patterns (DAMPs).

Main Methods:

  • Literature review and discussion of existing molecular data.
  • Analysis of signaling cascades initiated by CD95 engagement.

Main Results:

  • CD95 signaling can activate PRRs, which sense DAMPs.
  • This interaction may link CD95 to inflammatory processes.
  • Potential implications for cancer development and inflammatory/auto-immune disorders.

Conclusions:

  • CD95 signaling intersects with DAMP sensing pathways.
  • Understanding these connections is crucial for comprehending CD95's role in inflammation and disease.
Keywords:
CD95apoptosisauto-immunityinflammasomenecroptosispyroptosissting

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