SARS-CoV-2 Attacks in the Brain: Focus on the Sialome

Area of Science:

• Neuroscience
• Virology
• Immunology

Background:

• Epidemiological data link SARS-CoV-2 infection to neurological symptoms.
• The virus, SARS-CoV-2, shows potential for neuroinvasion.
• Cell membrane sialome interactions are implicated in SARS-CoV-2 neuroinvasion.

Purpose of the Study:

• To explore the role of the brain sialome in COVID-19 progression.
• To investigate the significance of the brain sialome in SARS-CoV-2-induced neuropathology.

Main Methods:

• Review of epidemiological observations.
• Analysis of scientific evidence on SARS-CoV-2 interactions with cell membrane sialome.
• Focus on the interplay between cell membrane sialoglycans and viral entry, transport, neuronal damage, and brain immunity.

Main Results:

• SARS-CoV-2 neurological manifestations are linked to its interaction with the cell membrane sialome.
• The brain's sialome plays a crucial role in viral attachment, cell entry, and subsequent neuropathology.
• Interactions influence neuronal damage and brain immune responses during COVID-19.

Conclusions:

• The brain sialome is a critical factor in the neuropathogenesis of COVID-19.
• Targeting sialome interactions may offer therapeutic strategies for SARS-CoV-2-related neurological complications.