Related Experiment Video

Updated: Sep 23, 2025

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
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Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

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Crosstalk of Autophagy and Apoptosis

Maurizio Sorice1

  • 1Department of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.

Cells
|May 14, 2022
PubMed

Insights

Autophagy and apoptosis are interconnected cell death processes. Understanding their crosstalk, influenced by calcium signaling and molecules like PINK1, offers new therapeutic strategies for cancer and rheumatic diseases.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Pathophysiology

Background:

  • Autophagy and apoptosis are critical cell fate mechanisms with interconnected signaling pathways.
  • Crosstalk between autophagy and apoptosis involves key molecules such as PINK1 and ERLINs.
  • Calcium (Ca2+) signaling plays a crucial role in mediating the crosstalk between autophagy and apoptosis.

Discussion:

  • The interplay between autophagy and apoptosis is implicated in various pathologies, notably rheumatic diseases.
  • This Special Issue explores the role of anthraquinone derivatives in regulating cell death and autophagy crosstalk.
  • Investigating drug bioactivity, particularly antitumor agents, is central to understanding these cell death pathways.

Key Insights:

  • Emerging research highlights the complex molecular mechanisms governing autophagy-apoptosis crosstalk.
  • PINK1 and ERLINs are examples of molecules involved in this intricate signaling network.
  • Calcium-dependent pathways are integral to the communication between autophagy and apoptosis.

Outlook:

  • Modulating autophagy-apoptosis crosstalk presents promising therapeutic avenues, especially in anti-cancer strategies.
  • Further research into drug-induced regulation of cell death pathways can yield novel treatments.
  • Understanding this crosstalk is vital for developing targeted therapies for cancer and rheumatic diseases.
Keywords:
PINK1apoptosisautophagycalciumcancer therapycell signalinglipid rafts

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