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Updated: Sep 23, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
10:27

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta

Published on: December 5, 2019

9.1K

The Role of E3 Ligase Pirh2 in Disease

Alexandra Daks1, Olga Fedorova1, Sergey Parfenyev1

  • 1Institute of Cytology RAS, 194064 St. Petersburg, Russia.

Cells
|May 14, 2022
PubMed

Insights

The Pirh2 ubiquitin ligase targets key proteins regulating cell functions. This review highlights Pirh2

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Cellular Biology

Background:

  • Pirh2 (p53-inducible RING-1) is a ubiquitin ligase with a crucial role in cancer.
  • It targets numerous proteins involved in cell proliferation, cell cycle, apoptosis, and migration.
  • Dysregulation of Pirh2 is implicated in various pathologies, particularly cancer.

Purpose of the Study:

  • To review the regulatory mechanisms of Pirh2.
  • To identify and summarize Pirh2's diverse protein targets.
  • To elucidate Pirh2's role in disease pathogenesis, focusing on cancer.

Main Methods:

  • Literature review of studies on Pirh2.
  • Analysis of experimental data on Pirh2 targets and functions.
  • Synthesis of information on Pirh2's involvement in disease.

Main Results:

  • Pirh2 regulates p53 family proteins, Chk2, p27Kip1, and Twist1, among others.
  • Pirh2 influences fundamental cellular processes including proliferation, cell cycle control, apoptosis, and migration.
  • Pirh2 is demonstrably involved in the initiation and progression of various cancers and other diseases.

Conclusions:

  • Pirh2 is a key regulator of critical cellular pathways.
  • Its multifaceted role in disease progression underscores its significance.
  • Pirh2 represents a promising therapeutic target for cancer and other pathologies.
Keywords:
E3 ligaseHIV-1Pirh2RCHY1SARS-CoVcancernerve injuryp53 protein familyubiquitinationvirus infection

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