Related Experiment Video
Updated: Sep 23, 2025
10:08
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
3.6K
Nutrient-Response Pathways in Healthspan and Lifespan Regulation
Aleksandra Dabrowska1, Juhi Kumar1, Charalampos Rallis1
1School of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
Cells
|May 14, 2022
Summary
Biogerontology research uses diverse models to explore how diet and nutrient pathways impact lifespan. Scientists are uncovering insights into aging and age-related diseases through advanced techniques and pathway analysis.
Area of Science:
- Biogerontology
- Aging research
- Molecular biology
Background:
- Cellular and model organisms (yeasts, C. elegans, Drosophila, mice) are crucial for studying aging.
- Diet, nutrient signaling pathways, and lifespan regulation are key areas of investigation.
- Multi-omics and high-throughput screening advance understanding of aging processes.
Purpose of the Study:
- To review recent findings on nutrient-response pathways (IGF, mTOR) and their role in aging.
- To examine Genome-Wide Association Studies (GWAS) and Epigenome-Wide Association Studies (EWAS) related to lifespan and age-related diseases.
- To discuss current knowledge, challenges, and future directions in biogerontology.
Main Methods:
- Utilizing diverse model organisms for biogerontology research.
- Employing combinatorial drug treatments, mutagenesis, and high-throughput screens.
- Applying multi-omics approaches to study cellular metabolism, development, and aging.
Main Results:
- Significant progress in understanding the link between diet, nutrient signaling, and lifespan.
- New insights into the intricate cross-talk of growth and stress pathways.
- Enhanced comprehension of genetic and epigenetic factors influencing aging and age-related diseases.
Conclusions:
- Continued research into nutrient-response pathways and their modulation holds promise for healthy aging.
- Interventions targeting these pathways could ameliorate age-related diseases.
- Future research should focus on characterizing pathway architecture and cross-talk for therapeutic development.
Keywords:
Caenorhabditis elegansDrosophila melanogasterEWASGWASIGF-1TORC1metabolomemouseproteometranscriptometranslationyeastMore Related Videos
Related Concept Videos
01:22Diversity in Cell Signaling Responses
6.8K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
6.8K
01:26Aging
207
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
207
01:31Regulation of the Unfolded Protein Response
2.6K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.6K
01:19Regulation of Metabolism
10.0K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.0K
01:19Interactions Between Signaling Pathways
6.6K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
01:28Global Regulatory Systems
91
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
91