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Updated: Sep 23, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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Current and Developing Liquid Biopsy Techniques for Breast Cancer.

Hsing-Ju Wu1,2,3, Pei-Yi Chu4,5,6,7,8

  • 1Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan.

Cancers
|May 14, 2022
PubMed
Summary
This summary is machine-generated.

Liquid biopsy offers a less invasive method for breast cancer diagnosis and monitoring by analyzing tumor components in biofluids. This review highlights advancements in liquid biopsy biomarkers and detection technologies like SERS and microfluidics.

Keywords:
breast cancercirculating tumor DNAcirculating tumor cellsextracellular vesiclesliquid biopsymicroRNA

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Area of Science:

  • Oncology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Breast cancer is a leading cause of cancer mortality globally.
  • Current diagnostic methods like mammography and biopsy have limitations.
  • Emerging personalized medicine and genetic profiling necessitate advanced diagnostic tools.

Purpose of the Study:

  • To review recent discoveries in tumor components and biomarkers for liquid biopsy in breast cancer.
  • To summarize novel detection techniques for liquid biopsy applications.
  • To highlight the potential of liquid biopsy as a less invasive diagnostic and monitoring tool.

Main Methods:

  • Review of recent scientific literature on breast cancer liquid biopsy.
  • Focus on circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), cell-free RNA (cfRNA), microRNA (miRNA), proteins, and extracellular vesicles (EVs).
  • Exploration of advanced detection methods including surface-enhanced Raman spectroscopy (SERS) and microfluidic devices.

Main Results:

  • Identification of various tumor components and biomarkers in biofluids for breast cancer detection.
  • Advancements in sensitive and specific detection techniques for these biomarkers.
  • Demonstration of liquid biopsy's potential for less invasive diagnosis and therapy monitoring.

Conclusions:

  • Liquid biopsy represents a promising, less invasive approach for breast cancer management.
  • Continued research into biomarkers and detection technologies will enhance liquid biopsy's clinical utility.
  • Liquid biopsy aids in personalized medicine and genetic profiling for breast cancer patients.