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The SARS-CoV-2 Pandemic and Cancer Trials Ireland: Impact, Resolution and Legacy.

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The COVID-19 pandemic significantly disrupted cancer clinical trials in Ireland, reducing accrual by over 50%. Adaptive strategies are crucial for a sustainable clinical trials ecosystem.

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Area of Science:

  • Oncology
  • Clinical Trials
  • Public Health

Background:

  • Cancer Trials Ireland (CTI) is the national cooperative group.
  • The SARS-CoV-2 pandemic caused significant healthcare disruption from March 2020 onwards.
  • The impact on CTI was assessed.

Purpose of the Study:

  • To assess the impact and legacy of the SARS-CoV-2 pandemic on Cancer Trials Ireland.
  • To identify and address pandemic-related disruptions in cancer clinical trials.
  • To develop adaptive strategies for a sustainable clinical trials ecosystem.

Main Methods:

  • Reviewed communications, logs, and trial data (2019-2021).
  • Conducted an online survey of investigators and clinical trials units.
  • Organized a National Cancer Retreat to discuss pandemic impact and strategies.

Main Results:

  • Cancer trial accrual decreased by 54%, with radiotherapy trials down 90%.
  • Trial initiations fell by 67%, and monitoring was reduced.
  • Remote working and telehealth were widely adopted; staff reassignments were common.

Conclusions:

  • The pandemic significantly and negatively impacted Irish cancer clinical trial activity.
  • Adaptive strategies are essential, including trial flexibility, telehealth, and remote monitoring.
  • Priorities include harmonizing processes and supporting research staff for a sustainable system.