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Updated: Sep 23, 2025
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
Current Pathology Model of Pancreatic Cancer
Krzysztof Szymoński1,2, Katarzyna Milian-Ciesielska2, Ewelina Lipiec3
1Department of Pathomorphology, Jagiellonian University Medical College, 31-531 Cracow, Poland.
Abstract:
Pancreatic cancer (PC) is one of the most aggressive and lethal malignant neoplasms, ranking in seventh place in the world in terms of the incidence of death, with overall 5-year survival rates still below 10%. The knowledge about PC pathomechanisms is rapidly expanding. Daily reports reveal new aspects of tumor biology, including its molecular and morphological heterogeneity, explain complicated "cross-talk" that happens between the cancer cells and tumor stroma, or the nature of the PC-associated neural remodeling (PANR). Staying up-to-date is hard and crucial at the same time. In this review, we are focusing on a comprehensive summary of PC aspects that are important in pathologic reporting, impact patients' outcomes, and bring meaningful information for clinicians. Finally, we show promising new trends in diagnostic technologies that might bring a difference in PC early diagnosis.
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