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[Pharmacokinetic research on theophylline]
Farmakologiia I Toksikologiia
|January 1, 1987
Summary
This study measured theophylline serum concentrations in healthy volunteers and patients with bronchospastic syndrome after intravenous and oral administration of euphylline. Peak concentrations were reached faster with intravenous injection compared to oral administration.
Area of Science:
- Pharmacology
- Clinical Chemistry
- Respiratory Medicine
Background:
- Theophylline is a bronchodilator used for managing bronchospastic syndromes.
- Understanding the pharmacokinetics of theophylline administration is crucial for effective treatment.
- Enzyme immunoassays provide a reliable method for quantifying drug serum concentrations.
Purpose of the Study:
- To compare blood serum theophylline concentrations after intravenous and oral euphylline administration.
- To determine the time to reach maximal theophylline concentration in healthy volunteers and patients with bronchospastic syndrome.
Main Methods:
- Enzyme immunological assay using a commercial kit ('Fedesim').
- Administration of euphylline at a dose of 5 mg/kg to 6 volunteers and 8 patients.
- Measurement of serum theophylline concentrations at various time points.
Main Results:
- Maximal theophylline concentration was achieved in volunteers at 15 minutes after intravenous injection.
- Maximal theophylline concentration was achieved in volunteers at 90 minutes after oral administration.
- Patients with bronchospastic syndrome showed a slightly delayed time to reach maximal concentration compared to volunteers.
Conclusions:
- Intravenous euphylline leads to a rapid increase in serum theophylline concentrations.
- Oral euphylline administration results in a slower absorption and delayed peak concentration.
- Theophylline pharmacokinetics may differ between healthy individuals and patients with bronchospastic conditions.