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Related Experiment Video

Updated: Sep 23, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Vitamin D in Osteosarcopenic Obesity.

Luigi Di Filippo^1,2, Rebecca De Lorenzo^1,3, Andrea Giustina^1,2

¹School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, 00132 Milan, Italy.

|May 14, 2022

Summary

Vitamin D deficiency may contribute to osteosarcopenic obesity, a condition of low bone and muscle mass in obese individuals. However, clinical evidence supporting vitamin D supplementation for this condition is currently lacking.

Keywords:

insulin resistance obesity osteopenia osteoporosis sarcopenia sarcopenic obesity vitamin D

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Area of Science:

Endocrinology
Metabolism
Gerontology

Background:

Osteosarcopenic obesity is characterized by coexisting low bone and muscle mass in obese individuals.
Adipose tissue, skeletal muscle, and bone are interconnected, with vitamin D influencing musculoskeletal health and glucose homeostasis.

Purpose of the Study:

To review the literature on the mechanisms of osteosarcopenic obesity.
To focus on the role of vitamin D in the pathogenesis and treatment of osteosarcopenic obesity.

Main Methods:

Literature review of existing studies.
Analysis of pre-clinical experiments and observational data.
Examination of clinical trials on vitamin D supplementation.

Main Results:

Observational studies and pre-clinical data suggest vitamin D deficiency contributes to osteosarcopenic obesity.
Clinical evidence for vitamin D supplementation improving musculoskeletal health in this condition is limited.
Existing trials show no or potentially detrimental effects of vitamin D on muscle and bone health in other populations.

Conclusions:

Further large-scale observational and interventional studies are needed.
Research should include diverse populations (sex, age, race) with osteosarcopenic obesity.
The precise role of vitamin D in osteosarcopenic obesity requires further investigation.