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Relationship between Serum 25-Hydroxyvitamin D Level and Risk of Recurrent Stroke.

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  • 1Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou 510317, China.

Nutrients
|May 14, 2022
PubMed
Summary

Maintaining optimal vitamin D levels may reduce the risk of recurrent stroke. A study found that serum 25-hydroxyvitamin D levels around 60 nmol/L were associated with the lowest risk of stroke recurrence.

Keywords:
25-hydroxyvitaminrecurrent strokestroke preventionvitamin D

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Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Limited evidence exists on the association between vitamin D and recurrent stroke risk.
  • Understanding this relationship is crucial for stroke prevention strategies.

Purpose of the Study:

  • To assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of recurrent stroke.
  • To identify the optimal 25(OH)D level associated with the lowest risk of recurrent stroke.

Main Methods:

  • Analysis of data from the prospective United Kingdom Biobank cohort.
  • Inclusion of 6824 participants with a history of stroke.
  • Utilized Cox proportional hazards regression with restricted cubic splines to model the dose-response relationship.

Main Results:

  • A quasi J-shaped relationship was observed between 25(OH)D levels and recurrent stroke risk.
  • The lowest risk of recurrent stroke was associated with 25(OH)D levels of approximately 60 nmol/L.
  • A 25(OH)D level of 60 nmol/L showed a 48% reduction in recurrent stroke risk compared to 10 nmol/L.

Conclusions:

  • Serum 25(OH)D levels exhibit a quasi J-shaped association with recurrent stroke risk in individuals with a prior stroke.
  • Optimal vitamin D status, around 60 nmol/L, may be linked to a reduced risk of recurrent stroke.
  • Further high-quality research is needed to establish causality and clarify vitamin D's role in recurrent stroke prevention.