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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

838
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 23, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Asian Race and Primary Open-Angle Glaucoma: Where Do We Stand?

Aditya Belamkar1, Alon Harris2, Francesco Oddone3

  • 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Journal of Clinical Medicine
|May 14, 2022
PubMed
Summary

Primary open-angle glaucoma (POAG) disproportionately affects Asian populations, with distinct structural and genetic factors influencing disease progression. Further research is crucial for effective treatment of normal-tension glaucoma in aging Asian demographics.

Keywords:
Asian populationcorneageneticsglaucomaintraocular pressurenormal tension glaucomaoptic nerve headprimary open angle glaucomaraceretina

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Area of Science:

  • Ophthalmology
  • Public Health
  • Genetics

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss globally.
  • POAG prevalence is projected to increase significantly, particularly in aging Asian populations.
  • Angle-closure glaucoma and normal-tension glaucoma show higher prevalence in Asian individuals.

Purpose of the Study:

  • To investigate the unique characteristics of POAG in Asian populations.
  • To understand the structural, genetic, and pathogenic differences in Asian POAG.
  • To highlight the need for tailored research and treatment strategies for Asian patients.

Main Methods:

  • Review of epidemiological data on POAG prevalence and risk factors.
  • Analysis of structural differences in the optic nerve head, retina, and cornea in Asian populations.
  • Examination of intraocular pressure (IOP) patterns and genetic associations.

Main Results:

  • Asian populations exhibit distinct structural characteristics relevant to glaucoma progression.
  • A significant inverse relationship between age and IOP was observed exclusively in Asian populations.
  • While genetic factors are implicated, clear patterns remain to be established.

Conclusions:

  • POAG pathogenesis and progression exhibit ethnic-specific variations, notably in Asian individuals.
  • Distinct structural and potential genetic factors contribute to POAG in Asians.
  • Increased awareness and targeted research are essential for managing the rising incidence of normal-tension glaucoma in aging Asian populations.