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Prostatic Abscess Caused by Klebsiella pneumoniae: A 6-Year Single-Center Study

Joo-Hee Hwang1,2, Jeong-Hwan Hwang1,2, Seung Yeob Lee2,3

  • 1Department of Internal Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.

Journal of Clinical Medicine
|May 14, 2022
PubMed

Insights

Hypervirulent Klebsiella pneumoniae (hvKp) causes prostatic abscesses, often linked to K1 capsular types and specific virulence genes. This highlights hvKp as a significant pathogen requiring clinical attention for effective treatment.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Urology

Background:

  • Hypervirulent Klebsiella pneumoniae (hvKp) strains are increasingly recognized for causing severe, multi-organ infections.
  • Prostatic abscesses are uncommon, and the role of hvKp in their etiology is poorly understood.
  • Limited data exists on the clinical significance of specific hvKp virulence factors in prostatic abscesses.

Purpose of the Study:

  • To investigate the clinical and microbiological features of prostatic abscesses caused by Klebsiella pneumoniae.
  • To determine the prevalence and characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in prostatic abscess cases.
  • To elucidate the association between specific virulence genes (K1/K2 capsular types, rmpA, iutA) and hvKp in prostatic abscesses.

Main Methods:

  • Retrospective study conducted at a tertiary hospital from January 2014 to December 2019.
  • Inclusion criteria: patients diagnosed with prostatic abscesses with Klebsiella pneumoniae isolated from cultures (blood, urine, pus, tissue).
  • Analysis of clinical data and microbiological characteristics, including capsular typing and virulence gene detection (rmpA, iutA).

Main Results:

  • Klebsiella pneumoniae accounted for 30.3% of prostatic abscesses in the study cohort.
  • All Klebsiella pneumoniae strains isolated from prostatic abscesses were of the K1 capsular type.
  • A high prevalence (80%) of hvKp markers (rmpA and iutA genes) was observed in these strains.

Conclusions:

  • Hypervirulent Klebsiella pneumoniae (hvKp), particularly K1 strains with rmpA and iutA genes, is a significant cause of prostatic abscesses.
  • Clinical awareness of hvKp's potential for bacteremia, multi-organ involvement, and metastatic spread is crucial for managing prostatic abscesses.
  • Further research is warranted to understand the full clinical impact and optimal management strategies for hvKp-associated prostatic abscesses.
Keywords:
Klebsiella pneumoniaehypervirulenceprostatic abscess

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