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Updated: Sep 23, 2025

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
Negative-Pressure Ventilation in Neuromuscular Diseases in the Acute Setting
Anna Annunziata1, Cecilia Calabrese2, Francesca Simioli1
1Department of Intensive Care, AORN Ospedali dei Colli, Via Leonardo Bianchi, 80131 Naples, Italy.
Abstract:
Mechanical ventilation started with negative-pressure ventilation (NPV) during the 1950s to assist patients with respiratory failure, secondary to poliomyelitis. Over the years, technological evolution has allowed for the development of more comfortable devices, leading to an increased interest in NPV. The patients affected by neuromuscular diseases (NMD) with chronic and acute respiratory failure (ARF) may benefit from NPV. The knowledge of the available respiratory-support techniques, indications, contraindications, and adverse effects is necessary to offer the patient a personalized treatment that considers the pathology's complexity.
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