Related Experiment Video
Updated: Sep 23, 2025
04:59
A Modified Vessel-Sparing Microsurgical Vasoepididymostomy
Published on: June 8, 2022
2.1K
Vascular dysfunction and increased cardiovascular risk in hypospadias
Angela K Lucas-Herald1,2, Augusto C Montezano1, Rheure Alves-Lopes1
1Institute of Cardiovascular and Medical Sciences, British Heart Foundation Centre for Research Excellence, University of Glasgow, 126 University Avenue, Glasgow G12 8TA, UK.
European Heart Journal
|May 14, 2022
Summary
Hypospadias, a condition linked to hypogonadism, is associated with impaired vascular function and increased cardiovascular disease risk in males. This study reveals underlying molecular mechanisms contributing to this risk.
Area of Science:
- Cardiovascular Science
- Endocrinology
- Developmental Biology
Background:
- Hypogonadism is a known risk factor for cardiovascular disease.
- The impact of developmental hypogonadism on cardiovascular health is not well understood.
- Hypospadias serves as a clinical indicator for studying hypogonadism during development.
Purpose of the Study:
- To investigate the association between hypospadias and vascular dysfunction.
- To determine if hypospadias is a risk factor for cardiovascular disease in males.
- To explore the molecular mechanisms underlying vascular impairment in hypospadias.
Main Methods:
- Clinical vascular phenotyping in adolescents with hypospadias and controls.
- Myography studies on small arteries to assess vascular function.
- Analysis of vascular smooth muscle cells for Rho kinase, ROS, and nitric oxide signaling.
- Epidemiological analysis of cardiovascular disease risk in men with a history of hypospadias.
Main Results:
- Adolescents with hypospadias showed increased blood pressure and carotid intima-media thickness.
- Arteries from boys with hypospadias exhibited impaired vasoconstriction and vasorelaxation.
- Men with hypospadias had a significantly higher risk of arrhythmia, hypertension, and heart failure.
Conclusions:
- Hypospadias is linked to vascular dysfunction and increased cardiovascular disease risk in adulthood.
- Perturbed Rho kinase and Nox5/ROS signaling pathways are implicated in the observed vascular injury.
- Hypospadias represents a significant cardiovascular risk factor in males, highlighting the importance of early assessment.
Related Concept Videos
01:21Nursing Assessment of the Genitourinary System I: Health History
86
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
86
01:20Disorders of the Male Reproductive System
641
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
641
01:20Vascular Resistance
5.7K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
5.7K
01:30Venous Thrombosis I: Introduction
49
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
49
01:26Varicose Veins I: Introduction
31
Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
31
01:24Esophageal Varices-I: Introduction
382
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
382