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Updated: Sep 23, 2025
08:01
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
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Targeting the CCL2-CCR2 axis for atheroprotection.
Marios K Georgakis1,2,3, Jürgen Bernhagen1,4,5, Laura H Heitman6,7
1Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, D-81377 Munich, Germany.
European Heart Journal
|May 14, 2022
Summary
Targeting the CCL2-CCR2 pathway offers a novel anti-inflammatory strategy for atherosclerosis. This approach focuses on specific immune mechanisms to reduce cardiovascular events while minimizing side effects.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Pharmacology
Background:
- Atherosclerosis is an inflammatory disease, with recent trials validating anti-inflammatory strategies for cardiovascular events.
- Targeting the inflammasome-interleukin pathway showed success but necessitates next-generation agents due to variable responses and side effects.
Purpose of the Study:
- To review experimental and human data on the CC-motif chemokine ligand 2/monocyte-chemoattractant protein-1 (CCL2/MCP-1) and its receptor CCR2 (CCL2-CCR2 axis) as a therapeutic target for atherosclerosis.
- To discuss the potential and challenges of targeting the CCL2-CCR2 pathway for cardiovascular disease treatment.
Main Methods:
- Summary of experimental atherosclerosis models.
- Analysis of genetic and observational epidemiological studies.
- Review of data from human atherosclerotic plaques.
Main Results:
- The CCL2-CCR2 pathway is crucial for inflammatory monocyte trafficking in atherosclerosis.
- Evidence from multiple studies highlights the therapeutic potential of targeting this axis in human atherosclerosis.
Conclusions:
- The CCL2-CCR2 pathway represents a promising, specific drug target for cardiovascular disease.
- Further research is needed to optimize strategies for targeting this pathway, considering ligand vs. receptor approaches and potential challenges.
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