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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

52
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
52
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
75
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

58
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Inflammation01:38

Inflammation

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Overview
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Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

44
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
44
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Predicts Premature Death In Acute Coronary Syndromes.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Predicts Premature Death In Acute Coronary Syndromes.

Related Experiment Video

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes.

Simon Kraler1, Florian A Wenzl1, Georgios Georgiopoulos2,3,4

  • 1Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, 8952 Schlieren, Zurich, Switzerland.

European Heart Journal
|May 14, 2022

View abstract on PubMed

Summary
This summary is machine-generated.

Elevated soluble LOX-1 (sLOX-1) in acute coronary syndromes (ACS) predicts mortality and plaque progression. Lower sLOX-1 levels correlate with coronary plaque regression in ACS patients.

Keywords:
Acute coronary syndromesAtherosclerosisInflammationLOX-1

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

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Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Atherosclerosis Pathogenesis

Background:

  • The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its soluble form (sLOX-1) are implicated in atherosclerotic cardiovascular disease (ASCVD).
  • Understanding the role of sLOX-1 in acute coronary syndromes (ACS) is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association of plasma sLOX-1 levels with fatal events and coronary plaque progression in patients with ACS.
  • To evaluate sLOX-1 as a predictive biomarker in ACS beyond established risk factors.

Main Methods:

  • Prospective recruitment of 2924 patients with ACS, chronic coronary syndrome (CCS), and healthy controls.
  • Measurement of plasma sLOX-1 at baseline and assessment of mortality risk at 30 days and 1 year.
Lipids
  • Serial intracoronary imaging in a subset of ACS patients to evaluate coronary plaque progression and regression in relation to sLOX-1 levels.

    • Main Results:

    • ACS patients exhibited significantly higher sLOX-1 levels compared to CCS patients and controls (35.08 pg/mL vs. 2.00 pg/mL).
    • Elevated sLOX-1 was independently associated with increased 30-day (HR 3.11) and 1-year (HR 2.04) mortality risk, particularly cardiovascular mortality.
    • In ACS patients, a significant drop in sLOX-1 was observed with coronary plaque regression, and sLOX-1 showed good discrimination for predicting plaque progression (AUC 0.74).

    Conclusions:

    • Plasma sLOX-1 is elevated in ACS and serves as a significant predictor of fatal events, outperforming traditional and emerging risk factors.
    • Persistently high sLOX-1 levels are associated with coronary plaque progression in patients with established ASCVD.