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Updated: Sep 23, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Association between complete right bundle branch block and atrial fibrillation development
Fu-Tao Zhang1, Xiao-Jie Liu1, Dan-Qing Zhao1
1Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Insights
Complete right bundle branch block (CRBBB) is linked to a higher risk of developing atrial fibrillation (AF). This finding is significant for patients with cardiovascular diseases, highlighting CRBBB as a key indicator for AF development.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Background:
- Complete right bundle branch block (CRBBB) is a known predictor of atrial fibrillation (AF) recurrence post-pulmonary vein isolation.
- The relationship between CRBBB and the initial development of AF remains less understood.
Purpose of the Study:
- To investigate the association between CRBBB and the incidence of AF in a hospitalized patient cohort.
- To identify CRBBB as a potential risk factor for new-onset AF.
Main Methods:
- A retrospective study involving 2639 patients was conducted.
- CRBBB was defined by specific ECG criteria including prolonged QRS duration (≥120 ms) and characteristic waveforms in leads V1, V2, I, and V6.
- Multivariate logistic analysis was employed to assess associations with AF development.
Main Results:
- CRBBB was identified in 1.5% of the study population.
- Patients with CRBBB showed a significantly higher prevalence of AF compared to those without CRBBB (22.5% vs. 7.2%; p=0.001).
- CRBBB was independently associated with AF development (OR, 3.329; p=0.009), alongside other factors like age, valvular heart disease, and left atrial diameter.
Conclusions:
- Complete right bundle branch block is significantly associated with the development of atrial fibrillation in hospitalized patients with cardiovascular diseases.
- CRBBB may serve as an important clinical marker for predicting AF onset in this population.
Background:
Complete right bundle branch block (CRBBB) is an important predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation. However, the association between CRBBB and AF development remains unclear.
Methods:
We performed a retrospective study of 2639 patients (male, n = 1549; female, n = 1090; mean age, 58 ± 13 years). CRBBB was defined as a late R (R') wave in lead V1 or V2 with a slurred S wave in lead I and/or lead V6 with a prolonged QRS duration (≥120 ms).
Results:
Among the 2639 patients, CRBBB was detected in 40 patients (1.5%), and the prevalence of AF was 7.4% (196/2639). The proportion of patients with AF and CRBBB was higher than the proportion of patients with AF without CRBBB (22.5% vs. 7.2%; p = 0.001). In the forward multivariate logistic analysis, CRBBB (odds ratio [OR], 3.329; 95% confidence interval [CI], 1.350-8.211; p = 0.009), complete left bundle branch block (OR, 2.209; 95% CI, 1.238-3.940; p = 0.007), age (OR, 1.020; 95% CI, 1.005-1.035; p = 0.009), valvular heart disease (OR, 2.332; 95% CI, 1.531-3.552; p < 0.001), left atrial diameter (OR, 1.133; 95% CI, 1.104-1.163; p < 0.001), left ventricular ejection fraction (OR, 1.023; 95% CI, 1.006-1.041; p = 0.007), and class I or III anti-arrhythmic drug use (OR, 10.534; 95% CI, 7.090-15.651; p < 0.001) were associated with AF.
Conclusion:
Complete right bundle branch block was significantly associated with AF development in hospitalized patients with cardiovascular diseases.
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