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Factors associated with prognosis of upper limb function in branch atheromatous disease

Kazuhiro Tokuda1, Keisuke Hanada1, Takashi Takebayashi2

  • 1Department of Rehabilitation/Hanwa Memorial Hospital, Osaka, Japan.

Clinical Neurology and Neurosurgery
|May 14, 2022
PubMed

Insights

Age and infarct volume significantly impact upper limb recovery in patients with branch atheromatous disease (BAD). These factors are crucial for predicting functional outcomes after acute neurological events.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Stroke Rehabilitation

Background:

  • Branch atheromatous disease (BAD) is linked to corticospinal tract injury.
  • Early neurological deterioration (END) can occur in the acute phase of BAD.
  • Understanding upper limb prognosis in BAD is critical for patient care.

Purpose of the Study:

  • To investigate upper limb functional prognosis in acute BAD.
  • To identify factors influencing upper limb recovery after BAD.
  • To analyze the relationship between BAD, END, and functional outcomes.

Main Methods:

  • 108 subjects with BAD were analyzed.
  • Subjects were categorized into good and poor upper limb recovery groups.
  • Univariate and multivariate analyses assessed age, infarct volume, initial Fugl-Meyer assessment (FMA) score, and END.

Main Results:

  • Univariate analysis revealed significant differences in age and infarct volume.
  • Multivariate analysis identified age (OR 0.977) and infarct volume (OR 0.645) as significant predictors.
  • Both age and infarct volume were strongly associated with upper limb functional prognosis.

Conclusions:

  • Age and infarct volume are key determinants of upper extremity paralysis prognosis in BAD.
  • These findings aid in predicting functional recovery in BAD patients.
  • Further research can refine prognostic models for BAD-related neurological deficits.
Abstract

Keywords:
Acute phaseBranch atheromatous diseaseHemiplegiaRehabilitationStrokeUpper extremity

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