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Self-propelled micro/nanobots: A new insight into precisely targeting cancerous cells through intelligent and deep
Amir Hossein Meisami1, Milad Abbasi2, Sareh Mosleh-Shirazi3
1Department of Emergency Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:
Cancer overlooks are globally one of the most dangerous and life-threatening tribulations. While significant advances have been made in the targeted delivery of anti-cancer medications over the last few years, several challenges, such as low efficacy and strong toxic effects, remain to be addressed. Micro/nanomotors have been thoroughly studied for both effective cancer detection and treatment, as demonstrated by significant advancements in the architecture of smart and functional micro/nanomotor biomedical systems. Able to self-propelled within fluid media, micro/nanomotors have attractive vehicles to maximize the efficacy of tumor delivery. Here, we present the current developments in the delivery, detection, and imaging-guided treatment of micro/nanomotors in the clinical field, including cancer-related specific targeted drug delivery, and then discuss the barriers and difficulties encountered by micro/nanomotors throughout the medical process. Furthermore, this paper addresses the potential growth of micro/nanomotors for medical applications, and sets out the current drawbacks and future research directions for more advancement.
Insights
Micro/nanomotors show promise for targeted cancer drug delivery and treatment, overcoming limitations of current therapies. Further research is needed to address challenges for clinical application.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer remains a major global health threat with existing treatments facing challenges in efficacy and toxicity.
- Targeted drug delivery systems are crucial for improving anti-cancer medication outcomes.
- Micro/nanomotors offer a novel platform for advanced cancer detection and therapeutic strategies.
Purpose of the Study:
- To review the current advancements in micro/nanomotor applications for cancer detection, drug delivery, and imaging-guided treatment.
- To discuss the challenges and limitations hindering the clinical translation of micro/nanomotor technologies in oncology.
- To explore the future potential and research directions for micro/nanomotors in medical applications.
Main Methods:
- Review of recent literature on micro/nanomotor development and biomedical applications.
- Analysis of studies focusing on targeted cancer drug delivery using micro/nanomotors.
- Discussion of imaging-guided treatment strategies involving micro/nanomotors.
- Evaluation of barriers to clinical implementation and future research needs.
Main Results:
- Micro/nanomotors demonstrate potential for self-propelled, targeted delivery of anti-cancer drugs to tumors.
- Advancements in smart micro/nanomotor systems enhance their capabilities for cancer detection and treatment.
- Current research highlights specific applications in targeted drug delivery and imaging-guided therapies.
Conclusions:
- Micro/nanomotors represent a promising frontier in cancer therapy, offering enhanced tumor targeting and efficacy.
- Overcoming challenges related to toxicity, control, and clinical translation is essential for widespread adoption.
- Continued research and development are vital to unlock the full potential of micro/nanomotors in oncology.
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