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Materials and device design for advanced phototherapy systems.

Ju Seung Lee¹, Jiwon Kim¹, Yeong-Sinn Ye¹

¹School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

Advanced Drug Delivery Reviews

|May 14, 2022

Summary

Phototherapy offers a minimally invasive cancer treatment. This review covers optical electronics, photothermal, photo-activated chemotherapy, and photodynamic therapies, alongside drug delivery systems for enhanced treatment efficacy.

Keywords:

Drug delivery system Light delivery system Photo-activated chemotherapy Photo-dynamic therapy Photo-thermal therapy Phototherapy

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Area of Science:

Biomedical Engineering
Oncology
Materials Science

Background:

Phototherapy is a promising, minimally invasive cancer treatment modality.
Limited light penetration depth and precise light delivery remain challenges.
Advanced photopharmaceutical device systems can improve therapeutic efficiency.

Purpose of the Study:

To review diverse optical electronics for targeted light delivery in phototherapy.
To highlight various phototherapy approaches: photothermal, photo-activated chemotherapy, and photodynamic therapy.
To discuss integrated drug delivery systems for spatiotemporal agent delivery to tumors.

Main Methods:

Review of optical electronics for lesion illumination.
Analysis of light-absorbing, light-sensitive materials, and photosensitizers for different phototherapies.
Examination of drug delivery systems for targeted photopharmaceutical agent administration.

Main Results:

Diverse optical electronics enable targeted light delivery.
Photothermal, photo-activated chemotherapy, and photodynamic therapies offer distinct mechanisms.
Integrated drug delivery systems enhance spatiotemporal control of therapeutic agents.

Conclusions:

Photopharmaceutical device systems show potential for efficient phototherapy.
Addressing limitations in light penetration and delivery is crucial for clinical translation.
Further research into materials, devices, and drug delivery is needed for optimized cancer phototherapy.