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Spray dried powders for nasal delivery: Process and formulation considerations
Patrícia Henriques1, Ana Fortuna2, Slavomíra Doktorovová3
1Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; R&D, Drug Product Development, Hovione FarmaCiencia SA, Lisbon, Portugal.
Summary
Nasal powder formulations offer enhanced stability and bioavailability compared to liquids. Spray-drying is a scalable method to optimize particle properties for effective nasal drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biopharmaceutics
Background:
- Nasal drug delivery offers advantages like improved stability, residence time, and bioavailability over liquid formulations.
- Powders are a promising dosage form for nasal administration, with spray-drying enabling control over critical particle properties.
Purpose of the Study:
- To review nasal powder formulation and spray-drying processing for drug delivery.
- To emphasize the variables impacting nasal powder performance.
Main Methods:
- Literature review focusing on spray-drying of nasal powders.
- Analysis of physical, biological, and pharmacological factors influencing drug absorption.
- Examination of formulation and manufacturing parameters.
Main Results:
- Spray-drying allows optimization of particle size and shape for nasal deposition.
- Process parameters, particle properties, and formulation composition significantly affect product performance.
- Understanding these variables is crucial for successful nasal powder development.
Conclusions:
- Spray-drying is a versatile and scalable technique for producing nasal powders.
- Optimizing formulation and processing is key to achieving desired drug delivery outcomes via the nasal route.
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