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Updated: Sep 23, 2025

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Microfluidics meets 3D cancer cell migration.

Pranav Mehta1, Zaid Rahman2, Peter Ten Dijke3

  • 1Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands; Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ, Delft, The Netherlands.

Trends in Cancer
|May 14, 2022
PubMed
Summary
This summary is machine-generated.

This review highlights how 3D microfluidic models advance the study of tumor cell migration within the tumor microenvironment (TME). These models offer insights into cancer invasion and potential therapeutic strategies.

Keywords:
cancer-associated fibroblastscell migrationinterstitial flowmicrofluidicstumor microenvironment

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Area of Science:

  • Oncology
  • Biotechnology
  • Biomedical Engineering

Background:

  • Metastasis involves complex tumor cell migration into the tumor microenvironment (TME).
  • The extracellular matrix (ECM) is a key component of the TME influencing cell behavior.
  • Conventional models have limitations in replicating the TME's complexity.

Purpose of the Study:

  • To review recent advancements in studying cancer cell migration.
  • To explore the evolution of microfluidic strategies for TME research.
  • To visualize diverse tumor cell migration modes within physiologically relevant conditions.

Main Methods:

  • Focus on 3D matrix-based microfluidic models.
  • Investigate mechanobiological features of the TME.
  • Utilize microfluidics for functional interrogation and therapeutic manipulation.

Main Results:

  • Microfluidic models effectively recapitulate TME mechanobiological features.
  • These models enable the study of collective cancer cell migration and invasion.
  • Microfluidics allows visualization of various tumor cell migration modes.

Conclusions:

  • 3D microfluidic models provide significant advantages over traditional methods for studying tumor progression.
  • Microfluidic strategies are crucial for understanding the dynamic and complex nature of cancer cell migration in the TME.
  • This approach facilitates the investigation of therapeutic interventions targeting tumor invasion.