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Summary
Routine multichannel chemistry tests (SMAC) in asymptomatic patients frequently show abnormal values. However, most results lack clinical significance, questioning the efficacy of this common screening practice.
Area of Science:
- Family Medicine
- Clinical Chemistry
- Diagnostic Testing
Background:
- Screening laboratory tests are common in general health evaluations.
- The clinical utility of routine chemistry profiles in asymptomatic individuals is not well-established.
Purpose of the Study:
- To evaluate the use and results of multichannel chemistry tests (SMAC) in asymptomatic patients.
- To assess the clinical significance of abnormal findings in baseline chemistry profiles.
Main Methods:
- Retrospective analysis of 288 asymptomatic patients undergoing routine physical examinations.
- Review of Sequential Multiple Analysis Computerized (SMAC) test results.
Main Results:
- 71 patients (25%) had baseline SMAC tests.
- 43 patients (61%) exhibited at least one abnormal chemistry value.
- Most abnormal results were of minimal clinical importance and infrequently followed up.
Conclusions:
- Routine baseline SMAC testing in asymptomatic patients yields a high rate of abnormalities.
- The clinical significance and cost-effectiveness of routine SMAC screening require further investigation.