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Updated: Sep 23, 2025

Isolation and Flow Cytometric Analysis of Human Endocervical Gamma Delta T Cells

Isolation and Flow Cytometric Analysis of Human Endocervical Gamma Delta T Cells

Published on: February 6, 2017

Adequacy in Endocervical Curettage.

Roa Alqabbani¹, Joanna Chan¹, Allison Goldberg¹

¹Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

American Journal of Clinical Pathology

|May 15, 2022

Summary

This summary is machine-generated.

Adequate cellularity for diagnosing high-grade dysplasia (HGD) in endocervical curettage (ECC) specimens is approximately 10,000 cells. Lower cellularity, around 1,000 cells, is considered inadequate for accurate HGD diagnosis on ECC.

Keywords:

Endocervical curettage High-grade dysplasia Papanicolaou test

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Area of Science:

Gynecologic Pathology
Cervical Cancer Screening
Histopathology Quality Assurance

Background:

Specimen adequacy is crucial for Papanicolaou tests, but criteria for endocervical curettage (ECC) are lacking.
High-grade dysplasia (HGD) diagnosis relies on accurate cellularity assessment.
Establishing cellularity benchmarks for ECC is essential for quality assurance.

Purpose of the Study:

To determine the minimum acceptable cellularity for diagnosing HGD in ECC specimens.
To evaluate the role of p16 immunohistochemistry (IHC) in conjunction with ECC findings.
To provide evidence-based criteria for ECC specimen adequacy.

Main Methods:

Retrospective analysis of 51 patients with HGD diagnosed via loop electrosurgical excision procedure (LEEP) and preceding ECC.
Quantification of squamous cell cellularity in ECC specimens using Aperio eSlide Manager.
Comparison of cellularity between positive and negative ECCs for HGD using t-tests and IHC staining for p16 using chi-squared tests.

Main Results:

ECC specimens positive for HGD showed significantly higher cellularity (mean 10,165 cells) than negative specimens (mean 1,055 cells).
p16 IHC was more frequently applied to HGD-positive ECCs (50%) versus HGD-negative ECCs (3%).
Biopsies with negative ECC findings were more likely to undergo p16 IHC (51%) than those with positive ECC findings (7%).

Conclusions:

Approximately 10,000 cells are adequate, while 1,000 cells are inadequate for diagnosing HGD in ECC specimens.
p16 IHC is utilized as a 'rule-in' test for ECC, but its interpretation requires careful consideration of concurrent biopsy results.
Further research into laboratory techniques to optimize ECC cellularity is recommended.