Design and fabrication of field-deployable microbial biosensing devices
Hoang Long Pham1, Hua Ling2, Matthew Wook Chang1
1NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore 117456, Singapore; Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; Wilmar-NUS Corporate Laboratory (WIL@NUS), National University of Singapore, Singapore 117599, Singapore.
Novel microbial biosensing devices combine synthetic biology with advanced platforms for real-world applications. These innovative biosensors offer potential for environmental monitoring and diagnostics beyond laboratory settings.
Area of Science:
- Biotechnology
- Bioelectronics
- Materials Science
Background:
- Conventional diagnostic tools face limitations in cost, configuration, and operational requirements for field applications.
- Biosensors offer versatile applications in environmental monitoring, pathogen detection, and biomarker diagnostics.
- Advances in synthetic biology and bioelectronics are driving the development of new microbial biosensing devices.
Purpose of the Study:
- To review recent advancements in microbial biosensing devices.
- To discuss the integration of synthetic biosensors with deployment platforms.
- To explore challenges and future perspectives for real-world applications.
Main Methods:
- Review of recent literature on microbial biosensing devices.
- Analysis of advances in synthetic biology, bioelectronics, and materials science.
- Discussion of integration strategies for biosensor components and platforms.
Main Results:
- Development of novel microbial biosensing devices by integrating synthetic biosensors with advanced platforms.
- Demonstration of potential for sensitive detection in environmental and diagnostic applications.
- Identification of key challenges hindering widespread adoption.
Conclusions:
- Microbial biosensing devices hold significant promise for diverse real-world applications.
- Overcoming challenges in cost, scalability, and operational robustness is crucial for widespread adoption.
- Continued interdisciplinary research is essential to realize the full potential of these technologies.
