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Updated: Sep 23, 2025
Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
Published on: November 6, 2018
Development of gamma irradiated SSD-embedded hydrogel dyed with prodigiosin as a smart wound dressing: Evaluation in
Nora M Elkenawy1, Heba M Karam1, Dina S Aboul-Magd1
1Drug Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Egypt.
Abstract:
Burn wounds are prone to infections and cause a large amount of death worldwide. Although burn wound is sterile at the beginning but due to the risk factors such as prolonged hospital stay, immune suppression and burn affecting large surface area, it turns to infected burn. This study aims to examine the possible protective properties of silver sulfadiazine embedded in alginate macromolecule to prepare hydrogel. The prepared hydrogel dyed with prodigiosin was used as a smart wound dressing to treat burn wounds that were infected with S. aureus and E. coli. Rats were divided into four groups: (1) control group, (2) burn-infected with S. aureus and E. coli group, (3) burn-infected treated with silver nitrate cream group and (4) burn-infected gamma irradiated silver sulfadiazine-embedded hydrogel dyed with prodigiosin. The biochemical results verified the histopathological results and our findings showed that silver sulfadiazine-embedded hydrogel dyed with prodigiosin is an effective product in compared with silver nitrate cream.
