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Updated: Sep 23, 2025
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Published on: September 17, 2016
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The dynamic kidney matrisome - is the circadian clock in control?
Rebecca Preston1, Qing-Jun Meng1, Rachel Lennon2
1Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Summary
Mammalian circadian clocks regulate physiological processes. This review explores how kidney extracellular matrix and circadian rhythms interact, offering insights into kidney disease and circadian medicine.
Area of Science:
- Circadian Biology
- Nephrology
- Extracellular Matrix Biology
Background:
- Mammalian circadian clocks coordinate physiological processes for homeostasis.
- Circadian clock dysfunction is linked to diseases involving extracellular matrix abnormalities, like fibrosis.
- Kidney function, including proteinuria and filtration rate, exhibits robust circadian oscillation, suggesting 24-hour kidney clocks.
Approach:
- This review summarizes genetic and biochemical evidence linking kidney physiology and disease to the circadian system, focusing on the extracellular matrix.
- It examines experimental approaches to dissect circadian pathway roles in specific tissues.
- The review discusses the translational aspects of circadian biology and potential applications in kidney disease treatment.
Key Points:
- Cell-matrix interactions and extracellular matrix biomechanics regulate peripheral circadian clocks in a tissue-specific manner.
- A temporally resolved kidney matrisome can elucidate the interplay between extracellular matrix and intracellular timekeeping in the kidney.
- Circadian rhythms play a critical role in kidney function and disease pathogenesis.
Conclusions:
- Understanding the kidney's circadian matrisome is crucial for studying extracellular matrix-circadian clock interactions.
- Circadian medicine holds promise for novel therapeutic strategies in treating kidney diseases.
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