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Factors Affecting the Risk of Infection01:26

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Endocarditis I: Introduction01:25

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Urinary Tract Infection II: Pathophysiology01:25

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Updated: Sep 23, 2025

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Risk factors for persistent enterococcal bacteraemia: a multicentre retrospective study.

Linda Bussini1, Elena Rosselli Del Turco1, Zeno Pasquini2

  • 1Infectious Disease Unit, IRCCS Policlinico di Sant'Orsola, Bologna, Italy.

Journal of Global Antimicrobial Resistance
|May 15, 2022
PubMed
Summary

Persistent enterococcal bacteraemia (p-EB) is linked to hematologic malignancy, infective endocarditis, and daptomycin use. This condition increases mortality risk in hospitalized patients, underscoring the need for further investigation.

Keywords:
Enterococcal bacteraemiaEnterococcus spp.Persistent bacteraemia

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Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Persistent enterococcal bacteraemia (p-EB) is a serious condition with incompletely understood risk factors and outcomes.
  • Enterococcus species are significant causes of hospital-acquired infections, particularly bacteraemia.

Purpose of the Study:

  • To investigate the risk factors associated with persistent enterococcal bacteraemia (p-EB).
  • To evaluate the impact of p-EB on 30-day mortality in hospitalized adult patients.

Main Methods:

  • Retrospective analysis of 244 adult patients with enterococcal bacteraemia from 2011-2019.
  • Multivariable logistic regression identified risk factors for p-EB; Kaplan-Meier curves and Cox regression assessed 30-day mortality impact.

Main Results:

  • Persistent enterococcal bacteraemia (p-EB) occurred in 13.5% of cases.
  • Independent risk factors for p-EB included hematologic malignancy, infective endocarditis, and initial daptomycin treatment.
  • Mortality was higher in the p-EB group (32% vs. 18%), with p-EB being a potential predictor of 30-day mortality.

Conclusions:

  • Persistent enterococcal bacteraemia (p-EB) is associated with specific patient vulnerabilities and initial antibiotic choices, notably daptomycin.
  • p-EB may significantly influence patient mortality, highlighting its clinical importance.