[Material Investigation for the Development of Non-rigid Phantoms for CT-MRI Image Registration]

In radiotherapy, deformable image registration (DIR) has been frequently used in different imaging examinations in recent years. However, no phantom has been established for quality assurance for DIR. In order to develop a non-rigid phantom for accuracy control between CT and MRI images, we investigated the suitability of 3D printing materials and gel materials in this study.

We measured CT values, T₁ values, T₂ values, and the proton densities of 31 3D printer materials-purchased from three manufacturers-and one gel material. The dice coefficient after DIR was calculated for the CT-MRI images using a prototype phantom made of a gel material compatible with CT-MRI.

The CT number of the 3D printing materials ranged from -6.8 to 146.4 HU. On MRI, T₁ values were not measurable in most cases, whereas T₂ values were not measurable in all cases; proton density (PD) ranged from 2.51% to 4.9%. The gel material had a CT number of 111.16 HU, T₁ value of 813.65 ms, and T₂ value of 27.19 ms. The prototype phantom was flexible, and the usefulness of DIR with CT and MRI images was demonstrated using this phantom.

The CT number and T₁ and T₂ values of the gel material are close to those of the human body and may therefore be developed as a DIR verification phantom between CT and MRI. These findings may contribute to the development of non-rigid phantoms for DIR in the future.