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Updated: Sep 23, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Sansoninto-induced Lung Injury.

Kosaku Komiya^1,2, Marcelo Takahiro Mitsui³, Toru Watanabe³

¹Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.

Internal Medicine (Tokyo, Japan)

|May 15, 2022

Summary

This study reports the first case of drug-induced lung injury caused by Sansoninto. Discontinuing the medication led to symptom resolution, confirming the diagnosis.

Keywords:

Chinese herb Sansoninto drug-induced pneumonitis kampo

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Area of Science:

Pulmonology
Pharmacology
Toxicology

Background:

Drug-induced lung injury (DILI) is a significant concern in clinical practice.
Sansoninto, a herbal medication, is used for various conditions.

Observation:

A 70-year-old male presented with persistent dyspnea and pulmonary infiltrates.
Symptoms were unresponsive to antibiotic treatment.
The patient had recently increased his Sansoninto dosage.

Findings:

Discontinuation of Sansoninto resulted in gradual symptom improvement and resolution of pulmonary infiltrates.
Drug lymphocyte stimulation tests were positive for Sansoninto.
The patient was diagnosed with Sansoninto-induced lung injury.

Implications:

This case highlights the potential for herbal medications like Sansoninto to cause serious adverse pulmonary events.
Early recognition and discontinuation of the offending agent are crucial for managing DILI.
Further investigation into the specific components of Sansoninto (sansonin, bukuryo, senkyo, chimo, kanzo) may elucidate the underlying mechanisms of lung injury.