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Related Experiment Video

Updated: Sep 23, 2025

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation.

Brie Trusiano¹, Juselyn D Tupik¹, Irving C Allen^1,2

¹Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA.

Journal of Leukocyte Biology

|May 16, 2022

Summary

This summary is machine-generated.

Transient Receptor Potential Melastatin 8 (TRPM8) ion channels are key in regulating inflammation and immune responses. Understanding TRPM8

Keywords:

AMTB TRP cation channel colitis monocyte differentiation

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Area of Science:

Immunology and Molecular Biology: Focuses on the innate immune system's role in hyperinflammatory conditions.

Background:

Dysregulated inflammation is linked to aberrant activation or impaired inhibition of the innate immune system.
Membrane-bound Transient Receptor Potential (TRP) ion channels, permeable to cations, are central to leukocyte function and sensory neuron signaling.
TRPM8, a specific TRP channel, acts as a prostate cancer marker and is involved in cold sensing and sensory neuron signaling.

Discussion:

TRPM8 channels are found on tissue macrophages and sensory neurons, influencing inflammation and pain pathways.
Activation by compounds like menthol highlights TRPM8's role in sensory perception and potentially inflammatory modulation.
The channel's involvement in releasing calcitonin gene-related peptide (CGRP) suggests a role in neuro-immune interactions.

Key Insights:

TRPM8 ion channels are implicated in the complex mechanisms of inflammatory diseases.
The channel's presence on immune cells and neurons points to its dual role in immune response and sensory signaling.
TRPM8 activation by external stimuli offers potential therapeutic targets for inflammatory conditions.

Outlook:

Further research into TRPM8 function could reveal novel therapeutic strategies for inflammatory bowel disease and other hyperinflammatory conditions.
Investigating TRPM8's role in prostate cancer and sensory pathways may lead to new diagnostic or treatment approaches.
Understanding the interplay between TRPM8, immune cells, and the nervous system is crucial for advancing treatments for inflammatory disorders.