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Adverse Drug Reactions in Corona Virus Disease Patients Admitted to Intensive Care Unit: An Observational Study

Nazia Nazir1, Deepti Chopra2, Bharti Bhandari3

  • 1Department of Anesthesiology & Critical Care, Government Institute of Medical Sciences, Gautam Buddha University, Greater Noida, India.

Current Drug Safety
|May 16, 2022
PubMed

Insights

Adverse drug reactions (ADRs) occurred in 36 COVID-19 patients, with skin issues being most common. Female gender, polypharmacy, and comorbidities were risk factors for these reactions.

Area of Science:

  • Pharmacovigilance
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Adverse drug reactions (ADRs) in COVID-19 patients remain understudied.
  • Understanding ADR patterns is crucial for patient safety in intensive care settings.

Purpose of the Study:

  • To investigate the characteristics of suspected ADRs in a COVID-19 Intensive Care Unit (ICU).
  • To identify risk factors associated with ADR occurrence in critically ill COVID-19 patients.

Main Methods:

  • Cross-sectional analysis of case reports from COVID-19 ICU admissions (August-October 2020).
  • Evaluation of ADR types, involved systems, suspected drugs, onset, reversion, and management.
  • Identification of independent risk factors for ADRs.

Main Results:

  • 44 ADRs were reported in 36 out of 395 COVID-19 ICU patients.
  • Dermatological manifestations were the most frequent ADRs.
  • Remdesivir was the most commonly suspected drug; female gender, polypharmacy (>5 drugs), and comorbidities were significant risk factors.

Conclusions:

  • The use of experimental drugs in COVID-19 treatment necessitates careful safety monitoring.
  • Findings highlight the importance of vigilant patient surveillance for ADRs in the evolving landscape of COVID-19 critical care.
Abstract

Keywords:
ADRCOVID-19ICUmonitoringpharmacovigilancesafety

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