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Updated: Sep 23, 2025

Pre-clinical Model of Cardiac Donation after Circulatory Death

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

Donation After Cardiac Death in Children.

Hassan Argani¹

¹From the Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation

|May 16, 2022

Summary

Pediatric organ donation faces challenges, with waitlists outgrowing supply. This review examines donation after cardiac death (DCD) as a viable option for pediatric solid-organ transplantation, challenging its perceived inferiority to donation after brain death (DBD).

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Area of Science:

Pediatric transplantation
Organ donation and procurement
Medical ethics in donation

Background:

The demand for pediatric organ transplants significantly outpaces the rate of organ donation, leading to extended waitlists.
While donation after cardiac death (DCD) has increased the organ pool for adults, its application in pediatric transplantation remains limited.
Long-term graft survival is a critical factor in pediatric recipients, necessitating a re-evaluation of DCD versus donation after brain death (DBD).

Purpose of the Study:

To analyze existing literature on donation after cardiac death (DCD) for solid-organ transplantation in children.
To assess the feasibility and outcomes of DCD in the pediatric population.
To challenge the conventional view that DCD is less effective than DBD for pediatric solid-organ transplants.

Main Methods:

Systematic literature review of studies on pediatric DCD for solid-organ transplantation.
Extraction and analysis of data concerning DCD donor characteristics and transplant outcomes in children.
Comparison of DCD outcomes with established outcomes from DBD in pediatric recipients.

Main Results:

Data on DCD for pediatric solid-organ transplantation is scarce but growing.
Initial analyses suggest potential for successful pediatric DCD transplantation, though long-term data is still emerging.
Graft survival and patient outcomes require further investigation to fully compare DCD with DBD in children.

Conclusions:

Donation after cardiac death (DCD) represents an underutilized resource for pediatric solid-organ transplantation.
Further research and policy development are needed to expand DCD for children awaiting transplants.
Reconsidering the perceived inferiority of DCD compared to DBD is crucial for improving pediatric transplant rates and outcomes.