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Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Updated: Sep 23, 2025

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
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Zinc and its role in vitamin D function.

Ashton Amos1, Mohammed S Razzaque1

  • 1Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

Current Research in Physiology
|May 16, 2022
PubMed
Summary

Zinc and vitamin D work together to support overall health. Adequate levels of both minerals are crucial for bodily functions, while deficiencies can lead to various health issues.

Area of Science:

  • Nutrition Science
  • Endocrinology
  • Mineral Metabolism

Background:

  • Zinc and vitamin D are essential nutrients with interconnected roles in human health.
  • Deficiencies in either nutrient are linked to various systemic disorders.
  • Previous research suggests a correlation between zinc levels and vitamin D status.

Purpose of the Study:

  • To elucidate the intricate relationship between zinc and vitamin D.
  • To highlight the role of zinc in facilitating vitamin D functions.
  • To emphasize the importance of adequate zinc and vitamin D levels for maintaining health.

Main Methods:

  • Review of existing literature on zinc and vitamin D interactions.
  • Analysis of in vitro studies on human peritoneal macrophages.
Keywords:
DeficiencyInteractionsSourcesVitamin DZinc

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  • Examination of the biochemical roles of zinc as a cofactor for vitamin D.

    • Main Results:

    • Reduced blood zinc levels can predict vitamin D deficiency.
    • Zinc supplementation has been shown to increase vitamin D levels in certain populations.
    • Zinc acts as a cofactor for vitamin D-dependent gene transcription.
    • Vitamin D can influence zinc transporters, affecting zinc homeostasis.

    Conclusions:

    • Zinc and vitamin D are vital for maintaining a healthy musculoskeletal system and overall bodily functions.
    • Adequate concentrations of both zinc and vitamin D are necessary to prevent various health disorders.
    • Understanding their interplay is crucial for nutritional health strategies.