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Highly Efficient Separation of Ultratrace Radioactive Copper Using a Flow Electrolysis Cell
Yumi Sugo1, Shin-Ichi Ohira2, Hinako Manabe3
1Department of Radiation-Applied Biology Research, Takasaki Advanced Radiation Research Institute, National Institutes for Quantum Science and Technology, 1233 Watanuki, Takasaki, Gunma 370-1292, Japan.
ACS Omega
|May 16, 2022
Summary
Researchers developed a novel flow electrolysis method for efficient separation of copper-64 (64Cu) radioisotopes. This technique aids in preparing 64Cu for positron emission tomography cancer diagnostics.
Area of Science:
- Radiochemistry
- Nuclear Medicine
- Analytical Chemistry
Background:
- Copper-64 (64Cu) is crucial for positron emission tomography (PET) cancer diagnostics.
- Current methods for separating 64Cu from target materials can be inefficient.
- Developing advanced separation techniques is vital for improving diagnostic capabilities.
Purpose of the Study:
- To develop a highly efficient separation method for recovering 64Cu.
- To utilize a flow electrolysis (FE) system for radioisotope separation.
- To establish an alternative to conventional column chromatography for ultratrace radioisotope recovery.
Main Methods:
- Irradiating 64Ni target with a proton beam to generate 64Cu.
- Employing a flow electrolysis cell with selective adsorption and desorption potentials.
- Dissolving the target in HCl and eluting with 10 mmol/L HNO3.
Main Results:
- Selective adsorption of 64Cu using a reduction potential.
- Efficient recovery of deposited 64Cu via oxidation potential elution.
- Successful separation of femtomolar levels of 64Cu from target metals in approximately 30 minutes.
Conclusions:
- The developed FE system offers a highly efficient method for 64Cu separation.
- This technique provides a viable alternative to traditional column chromatography.
- The method is suitable for preparing 64Cu for PET cancer diagnostics.
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