Related Experiment Video
Updated: Sep 23, 2025
08:30
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
2.1K
Tissue Resident and Migratory Group 2 Innate Lymphoid Cells
Laura Mathä1, Fumio Takei2,3, Itziar Martinez-Gonzalez1
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.
Frontiers in Immunology
|May 16, 2022
Summary
Group 2 innate lymphoid cells (ILC2s) are dynamic immune cells that migrate between tissues during inflammation. This review explores recent findings on ILC2 migration and their role in type 2 inflammatory diseases.
Area of Science:
- Immunology
- Cell Biology
Background:
- Group 2 innate lymphoid cells (ILC2s) are key players in type 2 inflammation, traditionally viewed as tissue-resident.
- ILC2s are found in various mucosal and non-mucosal tissues in both mice and humans.
Purpose of the Study:
- To review recent findings on the migration patterns of ILC2s.
- To highlight the dynamic nature of ILC2s during inflammatory responses.
Main Methods:
- Literature review of recent studies on ILC2 migration in animal models.
- Analysis of ILC2 circulation, tissue infiltration, and egress during inflammation.
Main Results:
- Recent studies demonstrate that ILC2s can circulate between organs during inflammation.
- ILC2s exhibit migratory capabilities, moving within, into, and out of tissues.
Conclusions:
- ILC2s are not exclusively tissue-resident but possess migratory functions.
- Understanding ILC2 migration is crucial for elucidating their role in diverse type 2 inflammatory diseases.
Related Concept Videos
01:18Lymphoid Cells and Tissues
1.6K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.6K
01:23Cells of the Adaptive Immune Response
4.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.9K
01:28Cells of the Innate Immune Response
4.1K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
4.1K
01:15Secondary Lymphoid Organs
4.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
4.2K
01:22Introduction to Lymphatic and Immune System
9.1K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
9.1K
01:16Primary Lymphoid Organs
7.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
7.7K