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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: Sep 23, 2025

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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lncRNA-mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis.

Chao Peng1, Shuaikai Wang2, Jinxiu Yu3

  • 1Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

Biomed Research International
|May 16, 2022
PubMed
Summary

Long noncoding RNAs (lncRNAs) are implicated in cancer. This study identified specific lncRNAs, FAM182B and LOC105375785, with lower expression in invasive pituitary adenomas, suggesting their potential as diagnostic biomarkers.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are crucial in tumorigenesis and cancer progression.
  • The role of lncRNAs in invasive pituitary adenomas (PAs) development is largely uncharacterized.

Purpose of the Study:

  • To investigate the expression patterns and potential roles of lncRNAs in invasive PAs.
  • To identify novel biomarkers for the diagnosis of invasive PAs.

Main Methods:

  • lncRNA microarray analysis was conducted on invasive and noninvasive PAs.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed.
  • Differentially expressed lncRNAs were validated using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and analyzed via receiver operating characteristic (ROC) curves.

Main Results:

  • A total of 8872 lncRNAs were identified, with 81 upregulated and 165 downregulated in invasive PAs.
  • GO and KEGG analyses indicated associations with protein posttranslational modifications.
  • FAM182B and LOC105375785 showed significantly lower expression in invasive PAs and demonstrated diagnostic potential via ROC analysis.

Conclusions:

  • lncRNA expression profiles in invasive PAs were elucidated.
  • FAM182B and LOC105375785 are potential contributors to PA invasiveness and serve as candidate biomarkers for invasive PA diagnosis.