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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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What Makes Cirrhosis Irreversible?-Consideration on Structural Changes.

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  • 1Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.

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Cirrhosis may not be irreversible. Advanced cirrhosis involves parenchymal extinction and disorganized regeneration, leading to circulatory issues and potential irreversibility.

Keywords:
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Area of Science:

  • Hepatology
  • Pathology
  • Regenerative Medicine

Background:

  • Chronic liver diseases can lead to fibrosis and cirrhosis.
  • Previously, cirrhosis was considered irreversible.
  • Vascular alterations are critical in chronic liver disease progression.

Purpose of the Study:

  • To understand morphological changes in cirrhosis.
  • To identify factors contributing to cirrhosis irreversibility.
  • To challenge the dogma of irreversible cirrhosis.

Main Methods:

  • Morphological analysis of initial and advanced cirrhosis stages.
  • Examination of parenchymal and vascular structural changes.
  • Assessment of regenerative processes in advanced cirrhosis.

Main Results:

  • Initial cirrhosis shows septa formation without vascular changes.
  • Advanced cirrhosis features parenchymal extinction with intact vessels and ductules.
  • Disrupted hepato-biliary junctions and disorganized regenerative nodules observed.

Conclusions:

  • Regeneration in advanced cirrhosis leads to disorganized nodules.
  • This disorganized regeneration causes circulatory disorders and perpetuates injury.
  • These factors may contribute to the irreversibility of cirrhosis.