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Updated: Sep 23, 2025

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Engineered Bacteria-Based Living Materials for Biotherapeutic Applications.

Rabia Omer¹, Muhammad Zubair Mohsin¹, Ali Mohsin¹

¹State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Frontiers in Bioengineering and Biotechnology

|May 16, 2022

Summary

Engineered living materials (ELMs), particularly bacteria, are revolutionizing medicine. Synthetic biology enables these programmable microbes for targeted therapies against diseases like cancer and IBD.

Keywords:

biodiagnostic biotherapeutics engineered living materials multiplex diseases synthetic biology synthetic live therapy

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Area of Science:

Biotechnology and Synthetic Biology
Biomedical Engineering
Microbiology

Background:

Static, monofunctional materials are insufficient for future therapeutic needs.
Precision medicine demands advanced, dynamic solutions.
Engineered living materials (ELMs) offer a novel platform for treating intractable diseases.

Purpose of the Study:

To review the role of synthetic biology in developing engineered living materials (ELMs), focusing on bacteria.
To summarize recent advances in engineered bacterial-based therapies for cancer, inflammatory bowel diseases, and infections.
To discuss challenges and future directions in the field of ELMs for biotherapeutics.

Main Methods:

Utilizing synthetic biology to design and engineer novel living materials, primarily bacteria.
Engineering probiotics and other microorganisms for therapeutic applications.
Developing programmable bacteria capable of sensing disease environments and delivering targeted outputs.

Main Results:

Engineered bacteria demonstrate potential for diagnostic and targeted delivery applications.
Recent advances show promise in treating cancer, inflammatory bowel diseases, and infections.
ELMs facilitate *in situ* drug delivery, reducing systemic side effects and paving the way for regenerative medicine.

Conclusions:

Synthetic biology is crucial for creating advanced ELMs for biotherapeutic applications.
Engineered bacterial therapies represent a significant advancement in treating complex diseases.
Continued research in ELMs promises novel regenerative medicines and improved patient outcomes.