Three-Phases Interface Induced Local Alkalinity Generation Enables Electrocatalytic Glucose Oxidation in Neutral...

Area of Science:

• Electrochemistry
• Biosensors
• Materials Science

Background:

• Non-enzymatic glucose sensors offer an alternative to enzymatic biosensors.
• Current non-enzymatic methods require alkaline electrolytes due to hydroxide consumption, limiting their use with neutral biofluids.

Purpose of the Study:

• To develop a non-enzymatic glucose sensor capable of operating in neutral solutions.
• To address the limitation of alkaline pH requirements in non-enzymatic glucose detection.

Main Methods:

• Designed an air-solid-liquid triphase interface electrode.
• Integrated local alkalinity generation (via oxygen reduction reaction) and electrocatalytic glucose oxidation.
• Investigated tuning of detection range and sensitivity by varying electrocatalysts.

Main Results:

• Achieved a sufficiently high local pH at the triphase interface.
• Enabled electrochemical oxidation (detection) of glucose in neutral solutions.
• Demonstrated tunability of linear detection range and sensitivity by altering electrocatalysts.

Conclusions:

• The triphase electrode architecture successfully enables non-enzymatic glucose detection in neutral environments.
• This approach provides a new platform for advancing non-enzymatic sensor technology.
• Promotes practical applications of non-enzymatic sensors in real-world scenarios.